Lewis R A, Lewis M N, Tattersfield A E
Am Rev Respir Dis. 1984 May;129(5):691-5. doi: 10.1164/arrd.1984.129.5.691.
The effect of suggestion on the airway response to 10 inhalations of normal saline followed by doubling concentrations of isoproterenol was assessed in 12 normal and 30 asthmatic subjects. It was suggested that the first 5 saline solutions contained a bronchoconstrictor and that the second 5 contained a bronchodilator, or vice versa, and that the first 4 isoproterenol solutions were inert, whereas the last was a bronchodilator. Nine asthmatic, but no normal subjects, bronchoconstricted after saline inhalation, with a mean fall in specific airway conductance (SGaw) of 40%. This was dose-dependent and was abolished when inhalations were carried out at 37 degrees C 100% relative humidity. Suggestion did not affect the airway response to saline or isoproterenol in either group, but it did influence the subjective impression of airway caliber recorded on a visual analogue scale. In this study, the bronchoconstriction after saline inhalation, previously attributed to the effect of suggestion, was caused by airway cooling.
在12名正常受试者和30名哮喘患者中，评估了暗示对气道反应的影响，具体为吸入10次生理盐水后，再吸入浓度加倍的异丙肾上腺素。实验暗示，前5次生理盐水溶液含有支气管收缩剂，后5次含有支气管扩张剂，反之亦然；前4次异丙肾上腺素溶液无活性，而最后一次是支气管扩张剂。9名哮喘患者在吸入生理盐水后出现支气管收缩，但正常受试者无此现象，其比气道传导率（SGaw）平均下降40%。这是剂量依赖性的，当在37摄氏度、相对湿度100%的条件下吸入时，这种现象消失。暗示对两组受试者气道对生理盐水或异丙肾上腺素的反应均无影响，但确实影响了视觉模拟量表记录的气道管径主观印象。在本研究中，之前认为是暗示作用导致的吸入生理盐水后的支气管收缩，实际上是由气道冷却引起的。
