Takada N, Hodaka E, Umeda T
Gan To Kagaku Ryoho. 1983 Jun;10(6):1416-27.
The pre-operative radiotherapy and systemic chemotherapy is effective in reducing the size of tumor and making the tumor resectable. The results achieved with systemic chemotherapy are ultimately reflected in improved survival. Moreover, limb-saving procedure in the treatment of osteosarcoma has become possible with rationality in carefully selected patients. Sixty-seven patients with osteosarcoma within a range of 5 to 27 years of age were treated at Chiba Cancer Center Hospital in the recent 12 year-duration. Seventeen of 67 patients underwent en bloc resection for osteosarcoma of the femur, (12 patients) and the tibia (5 patients). No patients had evidence of local recurrence of the tumor and overall 15 patients are alive without distant metastasis after 9 to 120 months follow-up. Based on the effective chemotherapy schedule, the limb salvation in the treatment of osteosarcoma is most desirable if it is indicated without risk of decreased radicality of the treatment.
术前放疗和全身化疗在缩小肿瘤大小并使肿瘤可切除方面是有效的。全身化疗所取得的结果最终体现在生存率的提高上。此外，通过合理地精心挑选患者，骨肉瘤治疗中的保肢手术已成为可能。在过去12年中，千叶癌症中心医院治疗了67例年龄在5至27岁之间的骨肉瘤患者。67例患者中有17例接受了股骨骨肉瘤（12例）和胫骨骨肉瘤（5例）的整块切除。没有患者出现肿瘤局部复发的证据，在9至120个月的随访后，共有15例患者存活且无远处转移。基于有效的化疗方案，如果在不降低治疗根治性风险的情况下进行保肢治疗，那么在骨肉瘤治疗中进行保肢是最理想的。
