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抗原向食蟹猴小唾液腺的逆行性通路

Retrograde access of antigens to the minor salivary glands in the monkey Macaca fascicularis.

作者信息

Nair P N, Schroeder H E

出版信息

Arch Oral Biol. 1983;28(2):145-52. doi: 10.1016/0003-9969(83)90121-8.

DOI:10.1016/0003-9969(83)90121-8
PMID:6575746
Abstract

Several authors have postulated that the ducts of minor salivary glands may provide pathways for the presentation of oral antigens to cells involved in a local immune response. This would imply a retrograde passage of oral antigens into the minor salivary glands. Various sites of the oral mucosa of anaesthesized M. fascicularis monkeys were labelled topically with a multiple tracer consisting of horseradish peroxidase (HRP), ferritin and Indian ink for a continuous period of 4-5 h. Serial cryosectioning of labelled lips and soft palates revealed retrograde passage of this tracer deep into some of the corresponding minor salivary glands. Minor salivary gland ducts can therefore serve as "portal of entry" for oral antigens, at least in the M. fascicularis monkey.

摘要

几位作者推测,小唾液腺导管可能为口腔抗原呈递给参与局部免疫反应的细胞提供途径。这意味着口腔抗原逆行进入小唾液腺。对麻醉的猕猴口腔黏膜的不同部位连续4 - 5小时局部标记由辣根过氧化物酶(HRP)、铁蛋白和印度墨水组成的多重示踪剂。对标记的嘴唇和软腭进行连续冰冻切片显示,这种示踪剂逆行深入到一些相应的小唾液腺中。因此,至少在猕猴中,小唾液腺导管可作为口腔抗原的“入口”。

相似文献

1
Retrograde access of antigens to the minor salivary glands in the monkey Macaca fascicularis.抗原向食蟹猴小唾液腺的逆行性通路
Arch Oral Biol. 1983;28(2):145-52. doi: 10.1016/0003-9969(83)90121-8.
2
Local immune response to repeated topical antigen application in the simian labial mucosa.猕猴唇黏膜反复局部应用抗原后的局部免疫反应。
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Architecture of associations of minor salivary gland ducts and lymphoid follicles in Macaca fascicularis. An ultrastructural study.食蟹猴小唾液腺导管与淋巴滤泡的关联结构。一项超微结构研究。
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A crypto-lymphatic unit at the uvula of the monkey Macaca fascicularis. A light- and electron-microscopic study.猕猴(食蟹猴)悬雍垂处的一个隐密淋巴单位。光镜和电镜研究。
Cell Tissue Res. 1983;228(1):171-82. doi: 10.1007/BF00206275.
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Age-related decline of lymphoid-tissue components in the oral mucosa of the lip, cheek and soft palate of Macaca fascicularis.食蟹猴唇部、颊部和软腭口腔黏膜中淋巴组织成分的年龄相关性衰退。
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