Smith D H, Dalrymple J C
Aust N Z J Obstet Gynaecol. 1983 Feb;23(1):32-4. doi: 10.1111/j.1479-828x.1983.tb00155.x.
A comparison between midtrimester abortion induced by the intraamniotic injection of prostaglandin F2 alpha and abortion induced by prostaglandin F2 alpha in Tylose gel administered extraamniotically was made in a group of 40 patients. The induction-abortion interval in the extraamniotic group was 12.1 hours which was significantly shorter (P less than 0.001) than the intraamniotic group (27.6 hours). The placenta was expelled completely more often and there were no cervical lacerations using the extraamniotic method whereas 2 patients required repair of cervical lacerations after intraamniotic prostaglandin. Extraamniotic administration of prostaglandin F2 alpha in Tylose gel is recommended as a safe and more effective method for inducing midtrimester abortion than intraamniotic prostaglandin.
对40例患者进行了比较，一组通过羊膜腔内注射前列腺素F2α诱导中期妊娠流产，另一组通过羊膜外给予含前列腺素F2α的泰洛糖凝胶诱导流产。羊膜外组的引产至流产间隔时间为12.1小时，明显短于羊膜腔内组（27.6小时）（P<0.001）。羊膜外方法能更频繁地使胎盘完全排出，且未出现宫颈裂伤，而羊膜腔内注射前列腺素后有2例患者需要修复宫颈裂伤。推荐羊膜外给予含前列腺素F2α的泰洛糖凝胶，作为一种比羊膜腔内前列腺素更安全、更有效的中期妊娠流产引产方法。
