Mecucci C, Vermaelen K, Tricot G, Louwagie A, Michaux J L, Bosly A, Thomas J, Barbieri D, Van den Berghe H
Cancer Genet Cytogenet. 1983 Aug;9(4):376-81.
Anomalies of both No. 3 chromosomes, of the t(3q-; 3q+) type can be observed in human malignancy as reported previously. It is our experience that this anomaly is found predominantly in myeloproliferative disorders, as a rather rare event, though occurring more frequently than similar exchanges between other homologous chromosomes. Previous claims about a relationship between this anomaly and thrombocytosis could not be confirmed, but the features found in a few patients indicate that further research should be undertaken to clarify this point.
正如之前所报道的，在人类恶性肿瘤中可观察到3号染色体的异常，即t(3q-; 3q+)类型。我们的经验是，这种异常主要在骨髓增殖性疾病中发现，是一种相当罕见的事件，尽管其发生频率比其他同源染色体之间的类似交换更高。先前关于这种异常与血小板增多症之间关系的说法未能得到证实，但在少数患者中发现的特征表明，应进一步开展研究以阐明这一点。
