111铟标记的慢性粒细胞白血病急变期白血病细胞的动力学
Kinetics of 111In-labelled leukaemic cells in blast crisis of chronic myelocytic leukaemia.
作者信息
Yamauchi K, Sugihara M, Nagao T, Suzuki Y
出版信息
Scand J Haematol. 1983 Sep;31(3):221-8. doi: 10.1111/j.1600-0609.1983.tb00644.x.
The distribution within the body of autologous leukaemic cells labelled with 111In oxine was studied in 4 patients with blast crisis of chronic myelocytic leukaemia (CML) by means of serial samples and gamma camera imaging. Leukaemic cells of the blood initially entered the spleen and liver, and the major site of localization was the former rather than the latter. A portion of leukaemic cells, which rapidly entered the liver, left temporarily 3 h after reinjection. Leukaemic cells entered the spleen maximally at 3 or 24 h and then continued to leave gradually or rapidly up to 48 h. The majority of leukaemic cells in acute myelocytic leukaemia did not leave the spleen for up to 48 h. It is suggested that the destruction of sinusoidal structures of the spleen due to marked infiltration of leukaemic cells in CML impairs the effects of filtration in endothelial cells of sinusoids and facilitates the entry of leukaemic cells into sinusoids from splenic cords.
通过连续取样和γ相机成像，对4例慢性粒细胞白血病（CML）急变期患者体内用111铟奥克辛标记的自体白血病细胞的分布进行了研究。血液中的白血病细胞最初进入脾脏和肝脏，主要定位部位是前者而非后者。一部分迅速进入肝脏的白血病细胞在重新注射后3小时暂时离开。白血病细胞在3或24小时时最大程度地进入脾脏，然后在长达48小时内逐渐或迅速持续离开。急性髓细胞白血病中的大多数白血病细胞在长达48小时内未离开脾脏。有人提出，CML中白血病细胞的显著浸润导致脾脏窦状结构的破坏，损害了窦状内皮细胞的过滤作用，并促进白血病细胞从脾索进入窦状隙。
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