Heyns A D, Lötter M G, Kotzè H F, Wessels P, Pieters H, Badenhorst P N
J Clin Pathol. 1985 Feb;38(2):128-32. doi: 10.1136/jcp.38.2.128.
The survival of red cells labelled with indium-111 oxine in the circulation was determined. In vivo distribution at equilibrium and sites of deposition at the T50In--that is, the half life of labelled red cells--were quantitated with a scintillation camera and computer assisted image analysis. Although the rate of elution. Of 111In from the red cells was higher than that of chromium-51-disodium chromate, estimates of T50In and T50Cr corresponded reasonably well and were shortened in haemolytic anaemia. In normal subjects red cells were sequestered mainly in the liver and spleen. In five patients with different types of haemolytic anaemia two distinct patterns of red cell sequestration could be recognised: mainly splenic sequestration, and destruction of red cells in the liver, spleen, and the bone marrow. These patterns were expected for the particular disease studied.
对用铟 - 111 氧肟酸盐标记的红细胞在循环中的存活情况进行了测定。通过闪烁相机和计算机辅助图像分析对平衡状态下的体内分布以及在 T50In（即标记红细胞的半衰期）时的沉积部位进行了定量分析。尽管铟 - 111 从红细胞中的洗脱速率高于铬 - 51 - 重铬酸钠，但 T50In 和 T50Cr 的估计值相当吻合，且在溶血性贫血中均缩短。在正常受试者中，红细胞主要被隔离在肝脏和脾脏中。在 5 例不同类型溶血性贫血患者中，可识别出两种不同的红细胞隔离模式：主要为脾脏隔离，以及红细胞在肝脏、脾脏和骨髓中的破坏。这些模式与所研究的特定疾病相符。
