Brune D, Kjaerheim A, Hensten-Pettersen A, Marion L
Acta Odontol Scand. 1983 Jun;41(3):129-34. doi: 10.3109/00016358309162313.
A method for the study of in vivo corrosion of various dental materials such as amalgams, gold, and chromium-cobalt alloys combining implantation and nuclear tracer techniques is described. Radioactive and nonradioactive implants were inserted subcutaneously in the backs of two groups of rats. After 5 days all animals were killed. The adjacent tissue was submitted to histopathological examination. The animals exposed to radioactive amalgams and chromium-cobalt disks with activity levels of 2-4 mCi showed local tissue reactions identical to those seen in sham-operated animals--that is, inflammation and formation of granulation tissue. In contrast, the rats exposed to radioactive gold foils with activity levels of about 20 mCi suffered heavier damage at the implantation site, with loss of hair and some necrosis, in addition to the inflammation and granulation tissue formation. There was no kidney damage. The release of mercury, gold, or cobalt into the adjacent tissue and the kidney was measured by means of gamma-ray spectrometry.
描述了一种结合植入和核示踪技术研究各种牙科材料（如汞合金、金和铬钴合金）体内腐蚀的方法。将放射性和非放射性植入物皮下植入两组大鼠的背部。5天后处死所有动物。对相邻组织进行组织病理学检查。暴露于活度水平为2 - 4毫居里的放射性汞合金和铬钴盘的动物，其局部组织反应与假手术动物相同，即炎症和肉芽组织形成。相比之下，暴露于活度水平约为20毫居里的放射性金箔的大鼠，除炎症和肉芽组织形成外，植入部位损伤更严重，出现脱毛和一些坏死。未发现肾脏损伤。通过伽马射线光谱法测量汞、金或钴向相邻组织和肾脏的释放情况。
