Syrjänen S, Hensten-Pettersen A, Kangasniemi K, Yli-Urpo A
Biomaterials. 1985 May;6(3):169-76. doi: 10.1016/0142-9612(85)90005-5.
Biocompatibility of dental alloys has been tested both in vivo and in vitro. In addition, combinations of dissimilar alloys were investigated in relation to possible enhanced corrosion by galvanic effects. Implantation tests, cytotoxicity tests on epithelial cells, macrophages and erythrocytes were performed, and the results compared. The severity of tissue response in implantation tests corresponded to the nobleness of the casting alloys joined to amalgam. Similar results were obtained in the in vitro macrophage test. All the alloys except the high-gold alloy (LM-Hard) had a toxic effect on epithelial cells. The combination of the casting alloys with amalgam diminished the toxic effect. Three of the alloys (amalgam, LM-Hard and Midi low-gold alloy) caused a slight haemolysis. Poor correlation was obtained between the agarose overlay tests, the haemolysis tests and the implantation tests.
牙科合金的生物相容性已在体内和体外进行了测试。此外，还研究了不同合金组合因电偶效应可能增强的腐蚀情况。进行了植入试验、对上皮细胞、巨噬细胞和红细胞的细胞毒性试验，并对结果进行了比较。植入试验中组织反应的严重程度与与汞合金连接的铸造合金的贵金属性相对应。在体外巨噬细胞试验中也获得了类似结果。除高金合金（LM-Hard）外，所有合金对上皮细胞都有毒性作用。铸造合金与汞合金的组合降低了毒性作用。其中三种合金（汞合金、LM-Hard和Midi低金合金）引起了轻微溶血。琼脂糖覆盖试验、溶血试验和植入试验之间的相关性较差。
