Long H J, Diamond S S, Burningham R A, Raflo C P
Am J Vet Res. 1983 Jul;44(7):1375-7.
Systolic time interval recordings were performed serially on 104 healthy female New Zealand White rabbits and 51 rabbits with congestive heart failure (CHF) induced by chronic anthracycline drug therapy. The results were analyzed and the comparisons were made with studies of systolic time interval recordings of CHF in persons. In the rabbit, CHF is manifested by prolongation of the isovolumic contraction time, the preejection period (PEP), and by shortening of the left ventricular ejection time (LVET). The ratio of PEP/LVET was a sensitive indicator of left ventricular failure, with values in excess of 0.466 reflecting significant cardiac dysfunction at the 95% confidence level. The mean PEP/LVET = 0.337 +/- 0.66 in healthy rabbits and PEP/LVET = 0.502 +/- 0.075 in rabbits with CHF. The PEP index increased from 0.057 +/- 0.007 in healthy rabbits to 0.074 +/- 0.007 in rabbits with heart failure. The LVET index decreased from 0.173 +/- 0.007 in healthy rabbits to 0.166 +/- 0.010 in rabbits with CHF.
对104只健康雌性新西兰白兔和51只因长期蒽环类药物治疗诱发充血性心力衰竭（CHF）的兔子连续进行收缩期时间间期记录。对结果进行分析，并与人类CHF收缩期时间间期记录的研究进行比较。在兔子中，CHF表现为等容收缩时间、射血前期（PEP）延长，以及左心室射血时间（LVET）缩短。PEP/LVET比值是左心室衰竭的敏感指标，在95%置信水平下，该比值超过0.466反映存在明显的心脏功能障碍。健康兔子的平均PEP/LVET = 0.337±0.066，CHF兔子的PEP/LVET = 0.502±0.075。PEP指数从健康兔子的0.057±0.007增加到心力衰竭兔子的0.074±0.007。LVET指数从健康兔子的0.173±0.007降低到CHF兔子的0.166±0.010。
