Shulkes A, Allen R D, Hardy K J
Aust N Z J Surg. 1983 Apr;53(2):149-52. doi: 10.1111/j.1445-2197.1983.tb02417.x.
The meal stimulated neurotensin release was studied in morbidly obese patients in whom gastric partitioning was performed as treatment for the obesity. Basal neurotensin and the early postprandial response were not altered by the operation. However, the late phase response between 60 and 150 min was depressed, the integrated response being 1.27 (s.e.m. = 0.22) nmol/l. min postoperatively, to 1.66 (s.e.m. = 0.32) nmol/l. min preoperatively (P less than 0.05). As neurotensin is a peptide which inhibits gastric acid secretion and stimulates pancreatic bicarbonate release, long term ulcerogenic effects of gastric partitioning operations should be considered.
对接受胃分隔术治疗肥胖症的病态肥胖患者进行了研究，观察进食对神经降压素释放的影响。手术未改变基础神经降压素水平和餐后早期反应。然而，术后60至150分钟的晚期反应受到抑制，综合反应术前为1.66（标准误=0.32）nmol/（升·分钟），术后为1.27（标准误=0.22）nmol/（升·分钟）（P<0.05）。由于神经降压素是一种抑制胃酸分泌并刺激胰腺碳酸氢盐释放的肽，因此应考虑胃分隔术的长期致溃疡作用。
