Jetten A M, De Luca L M
Biochem Biophys Res Commun. 1983 Jul 29;114(2):593-9. doi: 10.1016/0006-291x(83)90821-5.
Retinol, like retinoic acid, can induce differentiation of two embryonal carcinoma cell lines. These cells contain the specific retinol binding proteins in the cytosolic fractions. No correlation was found between the levels of binding activity and the effectiveness of retinol to induce differentiation. Microsomal fractions of embryonal carcinoma cells catalyse mannosyl transfer from GDP-mannose to retinyl phosphate. The formation of mannosyl retinyl phosphate appears a constitutive property and can be a mechanism by which retinoids induce early cell surface changes during differentiation of embryonal carcinoma cells.
视黄醇与视黄酸一样，能够诱导两种胚胎癌细胞系发生分化。这些细胞在胞质组分中含有特定的视黄醇结合蛋白。未发现结合活性水平与视黄醇诱导分化的有效性之间存在相关性。胚胎癌细胞的微粒体组分催化甘露糖基从GDP-甘露糖转移至视黄基磷酸酯。甘露糖基视黄基磷酸酯的形成似乎是一种固有特性，可能是类视黄醇在胚胎癌细胞分化过程中诱导早期细胞表面变化的一种机制。
