Casoli C, Bonati A, Starcich B R
Cancer. 1983 Oct 1;52(7):1210-4. doi: 10.1002/1097-0142(19831001)52:7<1210::aid-cncr2820520714>3.0.co;2-n.
The authors have determined TdT levels in a case of Ph1-positive AML. Peripheral blood cells and bone marrow cells taken during the various phases of the disease were examined. Liquor cells were analyzed when symptomatic central nervous system involvement occurred. High TdT levels were found in all of the phases of the disease including the liquor. TdT eluted at various isoelectric points indicating a shifting of the activity to greater molarity during progress of the disease. Two different forms of TdT were present in the liquor. The authors speculate about the existence of a relation between TdT levels and Ph1-positive leukemia. They point out the importance of TdT levels as functional criterion of remission in acute leukemia. Finally, the existence of different forms of TdT could be the expression of a clonal selection caused by therapy or of a spontaneous clonal competition.
作者测定了1例Ph1阳性急性髓细胞白血病患者的末端脱氧核苷酸转移酶（TdT）水平。对疾病各阶段采集的外周血细胞和骨髓细胞进行了检查。当出现有症状的中枢神经系统受累时，对脑脊液细胞进行了分析。在疾病的所有阶段，包括脑脊液中，均发现TdT水平较高。TdT在不同的等电点洗脱，表明在疾病进展过程中活性向更高摩尔浓度转移。脑脊液中存在两种不同形式的TdT。作者推测TdT水平与Ph1阳性白血病之间存在关联。他们指出TdT水平作为急性白血病缓解的功能标准的重要性。最后，不同形式TdT的存在可能是治疗引起的克隆选择或自发克隆竞争的表现。
