Stockley R J, Eden O B
Med Pediatr Oncol. 1983;11(4):284-6. doi: 10.1002/mpo.2950110415.
The case of an infant with the clinical and haematological features of chronic myelomonocytic leukaemia is reported. The infant presented with a peripheral blood monocyte count of 12,000 cell/mm3 (12.0 X 10(9) cell/L) but no lymphadenopathy, hepatomegaly, nor splenomegaly. No treatment was given for 14 months during which time the monocytosis persisted. Myeloblasts then appeared abruptly in the peripheral blood reaching a peak of 1,500,000 cell/mm3 (1,500 X 10(9)/L). Cytotoxic chemotherapy was initially successful but the blast soon became resistant and the child died. Chronic myelomonocytic leukaemia is usually associated with the elderly and the significance of this case is discussed.
报告了1例具有慢性粒单核细胞白血病临床和血液学特征的婴儿病例。该婴儿外周血单核细胞计数为12,000个/立方毫米（12.0×10⁹个/升），但无淋巴结肿大、肝肿大或脾肿大。在14个月的时间里未进行治疗，在此期间单核细胞增多持续存在。随后外周血中突然出现成髓细胞，峰值达到1,500,000个/立方毫米（1,500×10⁹/升）。细胞毒性化疗最初取得成功，但原始细胞很快产生耐药性，患儿死亡。慢性粒单核细胞白血病通常与老年人相关，并对该病例的意义进行了讨论。
