Okuda M, Ohtsuka H, Kawabori S
Eur J Respir Dis Suppl. 1983;128 (Pt 1):7-15.
The aim of the present study has been to examine the pathophysiology of allergic rhinitis, and the number, distribution and antigen-reactivity of basophilic cells. Blown nasal secretions, nasal washings, scrapings and excised specimens of nasal mucosa were collected and examined cytologically and histologically in both light and electron microscopes. Antigen-induced histamine release was also studied in these specimens. The results indicate that migration of basophilic cells (mainly basophil leukocytes in the nasal secretion and predominantly mast cells in the epithelium) to the mucosal surface is characteristic for allergy and that the total number and the histamine content of these cells are sufficient to produce the nasal manifestation of allergy. In conclusion, this study provides evidence supporting our concept of the mechanism of nasal allergy, i.e., that allergic reaction to inhaled allergens is initiated on the mucosal surface, and not in the lamina propria.
本研究的目的是探讨变应性鼻炎的病理生理学，以及嗜碱性细胞的数量、分布和抗原反应性。收集鼻分泌物、鼻腔灌洗液、刮取物和切除的鼻黏膜标本，进行细胞学和组织学检查，包括光学显微镜和电子显微镜检查。还对这些标本进行了抗原诱导的组胺释放研究。结果表明，嗜碱性细胞（主要是鼻分泌物中的嗜碱性白细胞和上皮中主要为肥大细胞）向黏膜表面迁移是变应性的特征，并且这些细胞的总数和组胺含量足以产生变应性的鼻部表现。总之，本研究提供了证据支持我们关于鼻变应性机制的概念，即对吸入变应原的变应性反应始于黏膜表面，而非固有层。
