Chanda J J, Callen J P
Cutis. 1978 Jun;21(6):843-7, 871.
Sclerotic changes in the skin are most frequently caused by scleroderma. In those cases in which scleroderma is not implicated, careful historical, physical, histologic, and laboratory evaluation will allow an appropriate diagnosis to be made. In this way, appropriate therapy and prognostication can be given.
皮肤的硬化性改变最常见于硬皮病。在那些与硬皮病无关的病例中，通过仔细的病史、体格检查、组织学和实验室评估可做出恰当诊断。如此，便可给予恰当的治疗和预后判断。
