Keller F, Maiga M K, Koeppe P
Nuklearmedizin. 1983 Jun;22(3):155-8.
67Gallium was injected into 60 patients with malignant tumors and into 42 patients in whom malignant tumors had been excluded by clinical investigation. 67Ga kinetics in blood were evaluated by non-linear least square regression computer analysis according to an open 2-compartment model where elimination proceeds from the peripheral compartment. Parameters of 67Ga kinetics in tumor patients showed a bimodal distribution, as was also the case in patients without tumors. No difference could be demonstrated between kinetic parameters of tumor patients and patients without tumors. In 4 patients, 67Ga kinetics could be evaluated before and after treatment of their malignant tumors, but a decrease in the volume of distribution was the single alteration of kinetic parameters occurring after treatment. This decrease may be explained by a smaller peripheral compartment resulting from the loss of tumor mass after treatment. Nevertheless, we conclude that the evaluation of 67Ga kinetics in blood will provide only limited information about the presence, size and growth rate of malignant tumors in man.
向60例恶性肿瘤患者以及42例经临床检查排除恶性肿瘤的患者体内注射了67镓。根据一个开放的二室模型，通过非线性最小二乘回归计算机分析评估血液中67镓的动力学，其中消除过程从外周室开始。肿瘤患者体内67镓动力学参数呈双峰分布，无肿瘤患者也是如此。肿瘤患者和无肿瘤患者的动力学参数之间无差异。4例患者在恶性肿瘤治疗前后可评估67镓动力学，但分布容积减小是治疗后动力学参数发生的唯一改变。这种减小可能是由于治疗后肿瘤体积减小导致外周室变小所致。然而，我们得出结论，评估血液中67镓动力学只能提供关于人类恶性肿瘤的存在、大小和生长速率的有限信息。
