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[恶性黑色素瘤的热化疗——ACNU与热疗联合治疗小鼠]

[Thermochemotherapy for malignant melanoma--combination therapy of ACNU and hyperthermia in mice].

作者信息

Yamada K, Someya T, Shimada S, Ohara K, Kukita A

出版信息

Gan To Kagaku Ryoho. 1983 Oct;10(10):2179-87.

PMID:6578704
Abstract

The effect of a combination therapy of hyperthermia (43 degrees C, 30 min) and ACNU (10 mg/kg) on B 16 melanoma and C 24 melanoma in vivo was studied. This combination therapy was effective in both melanoma. In C 24 melanoma, remarkably the tumor regression and the partial destruction of the histological structure, were observed.

摘要

研究了热疗（43摄氏度，30分钟）与阿糖胞苷（10毫克/千克）联合治疗对体内B16黑色素瘤和C24黑色素瘤的效果。这种联合治疗对两种黑色素瘤均有效。在C24黑色素瘤中，明显观察到肿瘤消退和组织结构的部分破坏。

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Gan To Kagaku Ryoho. 1983 Oct;10(10):2179-87.
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Thermochemotherapy for malignant melanoma: combination therapy of ACNU and hyperthermia in mice.
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Distribution, excretion, and metabolism of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea (ACNU) in rats and mice after iv administration.静脉注射给药后，3-[(4-氨基-2-甲基-5-嘧啶基)甲基]-1-(2-氯乙基)-1-亚硝基脲（ACNU）在大鼠和小鼠体内的分布、排泄及代谢
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