Coexistent breast and vaginal granulocytic sarcoma.

A 34-year-old woman developed a granulocytic sarcoma of the breast coincident with the development of acute myelogenous leukemia. Subsequent to the induction of leukemia remission, marrow relapse was preceded by development of breast and vaginal granulocytic sarcomas on two separate occasions. Granulocytic sarcoma is occasionally reported to involve reproductive organs, but the coexistence in two such organs is indeed rare. When granulocytic sarcoma occurs at other sites, it often precedes the development of overt leukemia. For this reason, granulocytic sarcoma should be considered in the differential diagnosis of a pelvic mass especially in a patient in whom blood smears reveal unusual or early forms.