Ledger W L, Ellwood D A, Taylor M J
J Reprod Fertil. 1983 Nov;69(2):511-5. doi: 10.1530/jrf.0.0690511.
Cervical softening was induced in late pregnant sheep by infusion of PGE-2 into a cervical artery. The effect of this treatment was assessed by measurement of the extensibility in vitro of a strip of cervical tissue. After infusion of a saline/ethanol mixture extensibility was 2.84 X 10(-3) +/- 0.3 X 10(-3) min-1 (mean +/- s.e.m., N = 5); after infusion of PGE-2 it increased significantly (P less than 0.02) to 8.6 X 10(-3) +/- 1.8 X 10(-3) min-1 (N = 6). Infusion of PGE-2 did not increase uterine activity, and there was no significant change in the concentration of progesterone in the maternal jugular venous plasma. These data suggest that PGE-2 might act as a mediator of cervical softening in vivo and show that the cervix can soften in the absence of uterine contractions.
通过向怀孕后期绵羊的子宫颈动脉注入前列腺素E2（PGE - 2）来诱导子宫颈软化。通过测量子宫颈组织条带的体外伸展性来评估这种治疗的效果。注入生理盐水/乙醇混合物后，伸展性为2.84×10(-3)±0.3×10(-3)分钟-1（平均值±标准误，N = 5）；注入PGE - 2后，其显著增加（P < 0.02）至8.6×10(-3)±1.8×10(-3)分钟-1（N = 6）。注入PGE - 2并未增加子宫活动，并且母体颈静脉血浆中孕酮浓度没有显著变化。这些数据表明PGE - 2可能在体内作为子宫颈软化的介质起作用，并表明在没有子宫收缩的情况下子宫颈也可以软化。
