Weinblatt M E, Ortega J A, Kaplan S
Med Pediatr Oncol. 1983;11(5):339-42. doi: 10.1002/mpo.2950110509.
Relapse in children with acute lymphoblastic leukemia (ALL) on therapy may be due to development of a resistant clone of blast cells. Seven children who presented initially with the "common"-type, L1 lymphoblast relapsed with a morphologically different and more undifferentiated blast cell. All were male, with a median age of 12 years at initial presentation. One child who relapsed while off therapy was successfully reinduced and remains in hematologic remission on therapy. The remaining 6 children died within 10 months of relapse. Selection of a resistant clone of lymphoblasts by chemotherapy may be responsible for relapse in children with ALL and should be studied in hopes of controlling the disease.
急性淋巴细胞白血病（ALL）患儿在治疗过程中复发可能是由于原始细胞耐药克隆的形成。7名最初表现为“普通”型L1原始淋巴细胞的患儿复发时出现了形态不同且分化程度更低的原始细胞。所有患儿均为男性，初诊时中位年龄为12岁。1名在停止治疗期间复发的患儿成功再次诱导缓解，目前仍处于血液学缓解状态并接受治疗。其余6名患儿在复发后10个月内死亡。化疗选择出耐药的原始淋巴细胞克隆可能是ALL患儿复发的原因，对此应进行研究以期控制该疾病。
