Levin L S, Leaf S H, Jelmini R J, Rose J J, Rosenbaum K N
Oral Surg Oral Med Oral Pathol. 1983 Sep;56(3):267-74. doi: 10.1016/0030-4220(83)90008-7.
Teeth of seven patients from the Brandywine isolate who had dentinogenesis imperfecta (DI) type III were evaluated by clinical, radiologic, and scanning electron microscopic techniques. The deciduous and permanent teeth were opalescent, and there was marked attrition. Enamel pitting was present on some permanent teeth. Anterior open bites were found in all persons with complete permanent dentitions. Pulps of developing teeth were larger than normal during early development but rapidly became almost completely obliterated. There was increased constriction at the cementoenamel junctions. While radiolucencies were noted at the apices of teeth which had pulp exposures due to attrition, several patients had similar radiolucencies which could not be attributed to caries or attrition. Scanning electron microscopy showed a significant reduction in the number of dentin tubules on fractured dentin surfaces; calcospherites at the calcification front were either irregularly shaped or absent. A single tooth from a patient with DI type II was studied and had similar abnormalities on scanning electron microscopy, although tubules were easier to find and calcospherites at the calcification front were more regular than in DI type III. The findings in DI type III of enamel pitting, enlarged pulps early in tooth development, and radiolucencies at the apices of teeth without pulp exposures support the hypothesis that DI type II and DI type III are different disorders.
采用临床、放射学和扫描电子显微镜技术对来自布兰迪万分离株的7例患有III型牙本质发育不全（DI）的患者的牙齿进行了评估。乳牙和恒牙呈乳白色，且有明显磨损。部分恒牙存在釉质凹陷。所有恒牙列完整的患者均有前牙开合。发育中的牙齿的牙髓在早期发育阶段比正常情况大，但很快几乎完全闭锁。牙骨质釉质交界处的缩窄增加。虽然在因磨损导致牙髓暴露的牙齿根尖处观察到透射影像，但有几位患者有类似的透射影像，其并非由龋齿或磨损引起。扫描电子显微镜显示，断裂牙本质表面的牙本质小管数量显著减少；钙化前沿的钙球晶形状不规则或缺失。对1例II型DI患者的一颗牙齿进行了研究，其在扫描电子显微镜下有类似异常，尽管小管更容易发现，且钙化前沿的钙球晶比III型DI更规则。III型DI中釉质凹陷、牙齿发育早期牙髓增大以及无牙髓暴露的牙齿根尖处的透射影像等发现支持了II型DI和III型DI是不同疾病的假说。
