Lygidakis N A, Smith R, Oulis C J
Department of Medical Genetics, J. Radcliffe Hospital, Oxford, U.K.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 May;81(5):567-72. doi: 10.1016/s1079-2104(96)80048-5.
Opalescent teeth from five patients and nonopalescent teeth from six patients with osteogenesis imperfecta type I were examined with the scanning electron microscope and their appearances compared with those of teeth from normal persons. In opalescent teeth the main findings were a reduction in the number and variation in the size of the dentinal tubules that were irregularly embedded within the disturbed dentinal matrix and an abnormally smooth enamel-dentinal junction. Similar less marked dentinal abnormalities were found in the nonopalescent teeth from three patients. No abnormality was found in the enamel in any of the teeth examined. These findings suggest that in osteogenesis imperfecta teeth that appear normal may have defective dentine. This relevant to the current clinical classification of the disorder into subgroups according to the clinical presence or absence of affected teeth.
对5例Ⅰ型成骨不全患者的乳光牙和6例Ⅰ型成骨不全患者的非乳光牙进行扫描电子显微镜检查，并将其外观与正常人的牙齿进行比较。在乳光牙中，主要发现是牙本质小管数量减少且大小不一，这些小管不规则地嵌入紊乱的牙本质基质中，以及釉质-牙本质界异常光滑。在3例患者的非乳光牙中也发现了类似但不太明显的牙本质异常。在所检查的任何牙齿的釉质中均未发现异常。这些发现表明，在成骨不全中，看似正常的牙齿可能存在牙本质缺陷。这与目前根据患牙的临床存在与否将该疾病分为亚组的临床分类有关。
