Wikstrand J, Trimarco B, Buzzetti G, Ricciardelli B, de Luca N, Volpe M, Condorelli M
Acta Med Scand Suppl. 1983;672:105-10. doi: 10.1111/j.0954-6820.1983.tb01621.x.
Echocardiography was performed at every six months in hypertensives well controlled on metoprolol, 100 mg twice a day. After six months' treatment blood pressure was reduced from 177/110 mm Hg to 147/88 (p less than 0.02). LV wall thickness (septum + posterior wall) was unchanged 2.10 cm (2.14), and a significant drop in cardiac output (CO) to 5.0 l/min (6.1, p less than 0.02) was recorded (pretreatment values in brackets). After 24 months' treatment LV wall thickness was reduced to 1.94 cm (p less than 0.02), total peripheral resistance (TPR) to 17.3 mm Hg/l/min (23.4, p less than 0.02) and CO increased to 6.7 l/min (6.1, n.s.). After six months' treatment, there was thus a drop in BP with a significant drop in CO and unchanged TPR. After 24 months' treatment, however, CO was back to the pretreatment level and the drop in BP was entirely caused by a drop in TPR which was probably secondary to a reduction in the wall thickness of the arterial resistance vessels as judged by the relationship between the reduction in wall thickness in the LV and the reduction in TPR during the treatment.
对每天服用两次100毫克美托洛尔且血压控制良好的高血压患者，每六个月进行一次超声心动图检查。治疗六个月后，血压从177/110毫米汞柱降至147/88（p<0.02）。左心室壁厚度（室间隔+后壁）保持不变，为2.10厘米（2.14），心输出量（CO）显著下降至5.0升/分钟（6.1，p<0.02）（括号内为治疗前值）。治疗24个月后，左心室壁厚度降至1.94厘米（p<0.02），总外周阻力（TPR）降至17.3毫米汞柱/升/分钟（23.4，p<0.02），心输出量增加至6.7升/分钟（6.1，无显著差异）。因此，治疗六个月后，血压下降，心输出量显著下降，外周阻力不变。然而，治疗24个月后，心输出量恢复到治疗前水平，血压下降完全是由外周阻力下降引起的，根据治疗期间左心室壁厚度的减少与外周阻力减少之间的关系判断，外周阻力下降可能继发于动脉阻力血管壁厚度的减少。
