Wise R, Donovan I A, Drumm J, Dent J, Bennett S A
Antimicrob Agents Chemother. 1983 Aug;24(2):279-81. doi: 10.1128/AAC.24.2.279.
The intraperitoneal penetration of cefotetan was studied after a 1-g intravenous injection in 25 patients undergoing elective gastrointestinal surgery. Levels of peritoneal fluid were high within 10 min after administration and increased to 44% of the serum levels after 30 min, rising to 115% at 3 h. The mean concentration of cefotetan between 3 and 5 h after administration was 32.3 micrograms/ml. These findings suggest that 1 g of cefotetan administered before abdominal surgery would result in intraperitoneal cefotetan levels necessary to inhibit susceptible pathogens for 5 h or more.
对25例接受择期胃肠手术的患者静脉注射1克头孢替坦后,研究了其腹腔内渗透率。给药后10分钟内腹腔液水平较高,30分钟后升至血清水平的44%,3小时时升至115%。给药后3至5小时头孢替坦的平均浓度为32.3微克/毫升。这些研究结果表明,腹部手术前给予1克头孢替坦可使腹腔内头孢替坦水平达到抑制易感病原体5小时或更长时间所需的水平。