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小剂量阿糖胞苷治疗老年急性髓细胞白血病患者

[Small dose of ARA-C in the treatment of an elderly patient with acute myeloblastic leukemia].

作者信息

Takeyama H, Yano K, Ohoshima K, Satake T, Emi N, Sugihara T, Kawashima K

出版信息

Gan To Kagaku Ryoho. 1983 Nov;10(11):2418-22.

PMID:6579883
Abstract

A 79 year old man with a history of myocardial infarction and cerebral infarction was admitted to our hospital in August, 1982. The hematological examination showed anemia and leukopenia (myeloblast 12%), and bone marrow aspiration confirmed the diagnosis of acute myeloblastic leukemia (FAB, M2). Because his general condition was poor, he was treated with small dose of Ara-C (10 mg/m2/12 hr, subcutaneous injections), obtaining complete remission. In cases of acute myeloblastic leukemia in elderly patients where other intensive treatments are contraindicated, it appears to be useful to employ a method of small dose of Ara-C therapy.

摘要

一名有心肌梗死和脑梗死病史的79岁男性于1982年8月入住我院。血液学检查显示贫血和白细胞减少(原始粒细胞12%),骨髓穿刺确诊为急性髓系白血病(FAB,M2型)。由于他的一般状况较差,给予小剂量阿糖胞苷治疗(10mg/m²/12小时,皮下注射),获得完全缓解。在老年急性髓系白血病患者中,若其他强化治疗禁忌,采用小剂量阿糖胞苷治疗方法似乎是有效的。

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