Zlateva M, Maleva E
Eksp Med Morfol. 1978;17(2):99-103.
The authors examined the morphologic changes in the myocardium of male white rats one and two months after chronic intoxication with the preparation BOFATOX, used in doses of 1/20 and 1/100 of LD50 for a period of two and four months. They observed circulatory and dystrophic changes during the first month, but after prolongation of repapatory period up to two months found definite pathologic changes, manifested by small cicatrixes, focal granuloma, vascular sclerosis and the presence of slightly manifested regenerative processes.
作者研究了雄性白鼠在以1/20和1/100的半数致死量(LD50)的剂量使用制剂BOFATOX进行慢性中毒一至两个月后的心肌形态学变化。在为期两个月和四个月的时间里,他们在第一个月观察到了循环和营养不良性变化,但在将恢复期延长至两个月后发现了明确的病理变化,表现为小瘢痕、局灶性肉芽肿、血管硬化以及轻微的再生过程。