Dick P
Encephale. 1978;4(1):41-51.
Although its pharmacology is virtually identical with that of the tricyclic antidepressants, metapramine (19560 R.P.), i.e. methyl-5 methylamino-10 dihydro-10, 11 dibenzo (b,f) azepine, differs biochemically from the tricyclics in that it markedly enhances the turnover of norepinephrine without notably inhibiting the re-uptake of this amine. Differences in the therapeutic effects of metapramine and clorimipramine have been investigated in a double-blind clinical test. The possible relationship between these differences and the biochemistry of both compounds is discussed in terms of the monoaminergic hypotheses.
尽管甲胺丙二苯卓（19560 R.P.），即甲基-5-甲基氨基-10-二氢-10,11-二苯并（b,f）氮杂卓，其药理学与三环类抗抑郁药几乎相同，但其在生物化学方面与三环类药物不同，因为它能显著提高去甲肾上腺素的周转率，而对该胺的再摄取抑制作用不明显。在一项双盲临床试验中研究了甲胺丙二苯卓和氯米帕明治疗效果的差异。根据单胺能假说讨论了这些差异与两种化合物生物化学之间的可能关系。
