Wright S, Herrmann L
Arzneimittelforschung. 1976;26(6):1167-9.
The anticholinergic side-effects of tricyclic antidepressants are unpleasant for the patients. Lofepramine, a new tricyclic antidepressant, has in animal studies been shown to have weak anticholinergic effects and a low acute toxicity. The aim of the present study was to see whether these pharmacological properties led to a lower rate of side-effects in depressed patients. In a double-blind trial 40 outpatients were treated with lofepramine or amitriptyline. Assessments were made with the Hamilton Scale, the Wakefield Self-Assessment Scale and a Side-effect Scale. 33 patients completed the trial. Both drugs proved effective. There were small differences in favour of lofepramine both in therapeutic efficacy and frequency of side-effects.
三环类抗抑郁药的抗胆碱能副作用让患者很不舒服。洛非帕明是一种新型三环类抗抑郁药，动物研究表明其具有较弱的抗胆碱能作用和较低的急性毒性。本研究的目的是观察这些药理学特性是否会降低抑郁症患者的副作用发生率。在一项双盲试验中，40名门诊患者接受了洛非帕明或阿米替林治疗。使用汉密尔顿量表、韦克菲尔德自我评估量表和副作用量表进行评估。33名患者完成了试验。两种药物均被证明有效。在治疗效果和副作用发生率方面，洛非帕明均有细微优势。
