Skubitz K M, Craddock P R, Weisdorf D J, Niedel J E, LeBien T W, Kersey J H, Brunning R D, Parkin J L, Flynn P J, Hammerschmidt D E
JAMA. 1983 Dec 2;250(21):2957-60. doi: 10.1001/jama.250.21.2957.
A 50-year-old man had chronic myelogenous leukemia and entered a blast crisis that was both morphologically and histochemically lymphoid. The blasts contained terminal deoxyribonucleotidyl transferase and expressed lymphoblastic leukemia-associated antigen. He rapidly entered remission with vincristine sulfate and prednisone therapy. Nevertheless, his blasts displayed a marker generally considered unique to myeloid cells: they selectively bound the granulocyte chemotaxin N-formyl-Met-Leu-Phe. In addition, some cells contained granules resembling those of basophils or mast cells. Such mixed myeloid-lymphoid features in chronic myelogenous leukemia blast cells may reflect malignant transformation of a stem cell capable of both myeloid and lymphoid differentiation, or they may reflect the dedifferentiation as a feature of malignant change.
一名50岁男性患有慢性粒细胞白血病，进入了形态学和组织化学均为淋巴细胞性的原始细胞危象期。原始细胞含有末端脱氧核苷酸转移酶，并表达淋巴细胞白血病相关抗原。他接受硫酸长春新碱和泼尼松治疗后迅速进入缓解期。然而，他的原始细胞显示出一种通常被认为是髓系细胞特有的标志物：它们选择性地结合粒细胞趋化因子N-甲酰-蛋氨酸-亮氨酸-苯丙氨酸。此外，一些细胞含有类似于嗜碱性粒细胞或肥大细胞的颗粒。慢性粒细胞白血病原始细胞中的这种混合性髓系-淋巴细胞特征可能反映了能够进行髓系和淋巴系分化的干细胞的恶性转化，或者它们可能反映了作为恶性变化特征的去分化。
