Testas P, Bénichou J, Perrin N, Vieillefond A, Benhanou M
Eur Surg Res. 1978;10(2):146-52. doi: 10.1159/000128003.
Two canine models of cirrhosis induced by administration of dimethyl-nitrosamine (DMNA) alone or in combination with hepatic vein ligation, were studied. The criteria used for development of cirrhosis were not only the appearance of portal hypertension, ascites, biochemical disorders or retention of BSP but also the formation of histological lesions such as sclerotic transformation of the liver lobules together with nodular regeneration. According to these criteria, the experimental protocol consisting in hepatic vein ligation and prolonged administration of DMNA was successful in inducing in animals liver cirrhosis similar to human conditions.
研究了两种犬肝硬化模型，一种是单独给予二甲基亚硝胺（DMNA）诱导的，另一种是联合肝静脉结扎诱导的。用于判定肝硬化形成的标准不仅包括门静脉高压、腹水、生化紊乱或磺溴酞钠潴留的出现，还包括组织学病变的形成，如肝小叶的硬化性转变及结节性再生。根据这些标准，由肝静脉结扎和长期给予DMNA组成的实验方案成功地在动物中诱导出了类似于人类情况的肝硬化。
