血清、血小板衍生生长因子、血管加压素和佛波酯可提高瑞士3T3细胞内的pH值。
Serum, platelet-derived growth factor, vasopressin and phorbol esters increase intracellular pH in Swiss 3T3 cells.
作者信息
Burns C P, Rozengurt E
出版信息
Biochem Biophys Res Commun. 1983 Nov 15;116(3):931-8. doi: 10.1016/s0006-291x(83)80231-9.
PMID:6580905
Abstract
Addition of the growth-promoting agents phorbol esters, vasopressin, platelet-derived growth factor or fresh serum to quiescent cultures of Swiss 3T3 cells causes a significant increase in the uptake of 5,5-dimethyl oxazolidine-2-4-dione (DMO), a sensitive measure of intracellular pH. The results further indicate that cytoplasmic alkalinization is an early event associated with the action of a variety of mitogenic compounds.
摘要
向静止的瑞士3T3细胞培养物中添加促生长剂佛波酯、血管加压素、血小板衍生生长因子或新鲜血清，会使5,5-二甲基恶唑烷-2,4-二酮（DMO）的摄取量显著增加，DMO是一种测量细胞内pH值的灵敏指标。结果还表明，细胞质碱化是与多种促有丝分裂化合物作用相关的早期事件。
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