Akagi K, Tsuji H, Kajiwara E, Murai K, Shikata T
Clin Chim Acta. 1983 Nov 30;135(1):83-7. doi: 10.1016/0009-8981(83)90391-1.
The activities of serum acid ribonuclease (RNase) were determined in patients with malignant neoplasm or with renal failure. The levels were markedly increased in myelogenous leukemia and renal failure, and only slightly increased in solid cancers, lymphoid malignancies and multiple myeloma. These increases correlated significantly with serum LDH activity in myelogenous leukemia and with creatinine levels in other malignancies or renal failure. The acid RNase content of granulocytes was 22.7-fold higher than that of lymphocytes. The increase of serum acid RNase may suggest an increased granulocyte destruction in myelogenous leukemia and a reduced glomerular filtration in other malignant neoplasms and renal failure.
测定了恶性肿瘤患者或肾衰竭患者血清酸性核糖核酸酶（RNase）的活性。在骨髓性白血病和肾衰竭患者中，该水平显著升高，而在实体癌、淋巴系统恶性肿瘤和多发性骨髓瘤患者中仅略有升高。这些升高与骨髓性白血病患者的血清乳酸脱氢酶活性以及其他恶性肿瘤或肾衰竭患者的肌酐水平显著相关。粒细胞的酸性RNase含量比淋巴细胞高22.7倍。血清酸性RNase升高可能提示骨髓性白血病中粒细胞破坏增加，以及其他恶性肿瘤和肾衰竭中肾小球滤过减少。
