Fujimori C, Yamagishi H, Mizukuro T, Tanaka T, Hashimoto I
Gan To Kagaku Ryoho. 1983 Mar;10(3):792-8.
In 1976 Reddi et al. reported increase of serum Ribonuclease (RNase) in pancreatic cancer patients. In this study, the increase in serum RNase activity was observed in patients with pancreatic cancer, coincided with the report by Reddi et al. The increase was also observed in patients with advanced gastric cancer. Especially, in patients with cancer invasion into pancreas, high value was obtained. Patients with other cancers showed the elevation of RNase activities. Thus, the elevation of serum RNase level is not specific only to patients with pancreatic cancer. An selectric focusing test showed no distinguishable difference in patients with pancreatic cancer and healthy persons. In mice with transplanted tumor of pancreas, serum RNase increased. Simultaneously, histological dilatation of pancreatic ducts and destruction of acinus were observed. When pancreas was occupied by tumor, serum RNase was decreased. These results suggest that RNase is not produced by cancer cell but is released from pancreas itself.
1976年，雷迪等人报告称胰腺癌患者血清核糖核酸酶（RNase）升高。在本研究中，胰腺癌患者血清RNase活性升高，这与雷迪等人的报告一致。晚期胃癌患者也观察到了这种升高。特别是，癌症侵犯胰腺的患者，其血清RNase活性值较高。其他癌症患者也显示出RNase活性升高。因此，血清RNase水平升高并非胰腺癌患者所特有。等电聚焦试验显示，胰腺癌患者与健康人之间没有明显差异。在移植了胰腺肿瘤的小鼠中，血清RNase升高。同时，观察到胰腺导管的组织学扩张和腺泡的破坏。当胰腺被肿瘤占据时，血清RNase降低。这些结果表明，RNase不是由癌细胞产生的，而是从胰腺本身释放出来的。
