Stenszky V, Kozma L, Balazs C, Farid N R
Clin Invest Med. 1983;6(3):181-4.
We have typed 196 patients with Graves' disease from eastern Hungary (an iodine-deficient region) for HLA-A, -B, and -C antigens and 80 of the same patients for HLA-DR antigens. Our data confirm the previously described association of HLA-B8 and DR3 with Graves' disease, particularly in patients with ophthalmopathy. We also describe several new findings: an increase in the prevalence of HLA-BW35, particularly in combination with B8, among patients with ophthalmopathy and a slight increase in the prevalence of B8, DR7 among patients with ophthalmopathy. These results support the concept that MHC-linked susceptibility to Graves' disease is dose-dependent. Our results do not confirm a report suggesting that the prevalence of HLA-DR5 is increased among patients without ophthalmopathy in iodine-deficient areas: we found that the prevalence of HLA-DR5 was slightly decreased among patients with Graves' disease, with and without ophthalmopathy, in comparison with controls.
我们对来自匈牙利东部（一个缺碘地区）的196例格雷夫斯病患者进行了HLA - A、 - B和 - C抗原分型，对其中80例相同患者进行了HLA - DR抗原分型。我们的数据证实了先前描述的HLA - B8和DR3与格雷夫斯病的关联，特别是在患有眼病的患者中。我们还描述了几个新发现：在患有眼病的患者中，HLA - BW35的患病率增加，特别是与B8组合时，以及在患有眼病的患者中B8、DR7的患病率略有增加。这些结果支持了MHC连锁的格雷夫斯病易感性是剂量依赖性的概念。我们的结果不支持一份报告，该报告表明在缺碘地区无眼病的患者中HLA - DR5的患病率增加：我们发现，与对照组相比，患有格雷夫斯病的患者（无论有无眼病）中HLA - DR5的患病率略有下降。
