匈牙利IgG重链同种异型（Gm）与格雷夫斯病的关联。
The association of IgG heavy-chain allotypes (Gm) with Graves' disease in Hungary.
作者信息
Kozma L, Stenszky V, Kraszits E, Balazs C, Farid N R
机构信息
Megyei Verellato, Debrecen, Hungary.
出版信息
Exp Clin Immunogenet. 1985;2(3):154-7.
PMID:3939975
Abstract
In an Eastern Hungarian population of patients, we sought to confirm an association with IgG heavy-chain allotypes (Gm) with Graves' disease. We found an increase in the phenotype fb (chi 2(1) = 4.7, p less than 0.05) among the patient group compared to controls. The influence of Ig-linked genes to Graves' disease susceptibility is, thus, dose-dependent. We found no interaction between fb homozygosity and HLA-DR3 positivity in Graves' disease susceptibility.
摘要
在匈牙利东部的患者群体中，我们试图证实IgG重链同种异型（Gm）与格雷夫斯病之间的关联。我们发现，与对照组相比，患者组中fb表型增加（χ2(1)=4.7，p<0.05）。因此，Ig连锁基因对格雷夫斯病易感性的影响是剂量依赖性的。我们发现在格雷夫斯病易感性方面，fb纯合性与HLA-DR3阳性之间不存在相互作用。
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