Xu S W, Chen F, Chao Y H
Second Affiliated Hospital, Zhejiang Medical University, Hangzhou.
Zhonghua Zhong Liu Za Zhi. 1994 Jul;16(4):310-3.
From August 1990 to June 1993, 30 patients with osteosarcoma of lower extremities were treated with chemotherapy by hyperthermic regional isolated perfusion. There were 19 male and 11 female with a mean age of 21 (15-28) years. All of the tumors were located in the lower limbs: 20 on the femora, 9 on the tibiae and 1 on the fibula. Chemotherapy was going on for 60 minutes during hyperthermic regional isolated perfusion. Temperature was kept at 42 degrees C in deep soft tissue around the tumor during perfusion. The results showed that local edema of the limbs were reduced observably, tumors were shrunken and hardened after perfusion. Perimeter of the limbs were decreased and mobility of the limbs increased. Pathological examination indicated that all of the tumors responded well to the chemotherapy by perfusion and 90%-95% of the osteosarcoma cells were destroyed. Two cases were complicated with compression syndrome, and 1 with renal failure. The authors would suggest that hyperthermic regional isolated perfusion is an effective chemotherapeutic method in management of malignant tumors of limbs.
1990年8月至1993年6月，对30例下肢骨肉瘤患者采用高温区域隔离灌注化疗。其中男性19例，女性11例，平均年龄21岁（15 - 28岁）。所有肿瘤均位于下肢：股骨20例，胫骨9例，腓骨1例。高温区域隔离灌注期间化疗持续60分钟。灌注过程中肿瘤周围深部软组织温度保持在42℃。结果显示，灌注后肢体局部水肿明显减轻，肿瘤缩小变硬。肢体周长减小，肢体活动度增加。病理检查表明，所有肿瘤对灌注化疗反应良好，90% - 95%的骨肉瘤细胞被破坏。2例并发压迫综合征，1例并发肾衰竭。作者认为高温区域隔离灌注是治疗肢体恶性肿瘤的一种有效化疗方法。
