Hildebrand H F, Veron C
J Biol Buccale. 1983 Sep;11(3):209-25.
This study examined the effects of N-methyl-N'-nitro-N-nitrosoguanidine (M.N.N.G.) on the oral mucosa of Wistar rats. The rats were born from dams treated by i.p. injections of M.N.N.G. during gestation. Each pregnant rat of a first group received a total dose of 39.60 mg/kg of M.N.N.G. administered throughout the gestation period. Each pregnant rat of a second group received a total dose of 82.50 mg/kg of M.N.N.G. by i.p. injections during the first ten days of gestation. In the progeny of dams from both groups, the morphology of the gingiva was modified. The lingual gingiva from the lower jaw was most impaired. The epithelium always displayed hyperplasia: acanthosis, papillomatosis and hyperkeratosis. These results indicate a pathogenic effect of M.N.N.G. on lingual, mandibular gingiva. This effect was slight but permanent and irreversible. No carcinogenic effect was noticed on the oral mucosa. Similarities between the lesions described in this work and human epithelial dysfunction makes this experimental model interesting.
本研究检测了N-甲基-N'-硝基-N-亚硝基胍（M.N.N.G.）对Wistar大鼠口腔黏膜的影响。这些大鼠出生于孕期经腹腔注射M.N.N.G.处理的母鼠。第一组的每只孕鼠在整个妊娠期接受的M.N.N.G.总剂量为39.60毫克/千克。第二组的每只孕鼠在妊娠的前十天经腹腔注射接受的M.N.N.G.总剂量为82.50毫克/千克。在两组母鼠的后代中，牙龈形态发生了改变。下颌舌侧牙龈受损最为严重。上皮总是表现出增生：棘层肥厚、乳头瘤样增生和角化过度。这些结果表明M.N.N.G.对舌侧、下颌牙龈有致病作用。这种作用轻微但持久且不可逆。未观察到对口腔黏膜有致癌作用。本研究中描述的病变与人类上皮功能障碍之间的相似性使得这个实验模型很有意义。
