Kobori O, Shimizu T, Maeda M, Atomi Y, Watanabe J, Shoji M, Morioka Y
J Natl Cancer Inst. 1984 Oct;73(4):853-61.
The carcinogenic or cocarcinogenic effects of bile or bile acid on stomach carcinogenesis were investigated in inbred W rats. Bile or bile acid was introduced into the stomach by choledochogastrostomy or with food after the administration of N-methyl-N'-nitro-N-nitrosoguanidine [(MNNG) CAS: 70-25-7; 1-methyl-3-nitro-1-nitrosoguanidine] in drinking water. The animals that received MNNG and bile or sodium taurocholate (CAS: 145-42-6; N-choloyltaurine sodium salt) had a significantly higher incidence of hyperplastic and neoplastic lesions in the stomach mucosa than did the relevant MNNG-treated controls. The result suggested an enhancing effect of bile and sodium taurocholate in stomach tumorigenesis.
在近交系W大鼠中研究了胆汁或胆汁酸对胃癌发生的致癌或促癌作用。在给大鼠饮用含N-甲基-N'-硝基-N-亚硝基胍[（MNNG），化学物质登记号：70-25-7；1-甲基-3-硝基-1-亚硝基胍]的水后，通过胆总管造口术或将胆汁或胆汁酸与食物一起引入胃中。接受MNNG和胆汁或牛磺胆酸钠（化学物质登记号：145-42-6；N-胆酰牛磺酸钠）的动物，其胃黏膜增生性和肿瘤性病变的发生率明显高于相应的接受MNNG治疗的对照组。结果提示胆汁和牛磺胆酸钠对胃肿瘤发生有促进作用。
