Ericsson Y, Angmar-Månsson B
J Dent Res. 1983 Dec;62(12):1196-200. doi: 10.1177/00220345830620120401.
Alkaline and acid phosphatases (p-ases), fluoride (F), and calcium (Ca) were analyzed in the pulps of rat incisors and young human pre-molars. P-ase activities were about ten times higher in the rat than in the human pulps; in the latter, high p-ase activity appeared to be connected with rapid mineralization. Average total F was 3-4 ng/mg in both rat and human pulp, while Ca showed values several times higher, although greatly varying, in human than in rat pulps. Ionized F was two to three times higher in ultrafiltrates from rat and human pulps than in the blood plasma of the species; in the rat, the F content of the ultrafiltrates increased only three to four times when plasma F was experimentally elevated over 100 times. In vitro, rat pulp alk. p-ase activity was slightly inhibited only in the range above 100 mM NaF, while acid p-ase showed weak inhibition in the region from 0.15-0.25 mM and 40-60% inhibition in the range from 10-100 mM NaF. In vivo, no effect on pulp p-ases was found, even from sublethal NaF doses.
对大鼠切牙和年轻人类前磨牙牙髓中的碱性磷酸酶和酸性磷酸酶（磷酸酶）、氟化物（F）和钙（Ca）进行了分析。大鼠牙髓中的磷酸酶活性比人类牙髓中的高约10倍；在人类牙髓中，高磷酸酶活性似乎与快速矿化有关。大鼠和人类牙髓中的平均总氟含量均为3 - 4 ng/mg，而钙含量在人类牙髓中虽差异很大，但比大鼠牙髓中的高出数倍。大鼠和人类牙髓超滤液中的离子化氟比该物种血浆中的高两到三倍；在大鼠中，当血浆氟通过实验升高超过100倍时，超滤液中的氟含量仅增加三到四倍。在体外，仅在NaF浓度高于100 mM时，大鼠牙髓碱性磷酸酶活性略有抑制，而酸性磷酸酶在0.15 - 0.25 mM范围内表现出微弱抑制，在10 - 100 mM NaF范围内抑制率为40 - 60%。在体内，即使给予亚致死剂量的NaF，也未发现对牙髓磷酸酶有影响。
