Spoto G, Fioroni M, Rubini C, Tripodi D, Di Stilio M, Piattelli A
Department of Biochemical Sciences, Dental School, University of Chieti, Italy.
J Endod. 2001 Mar;27(3):180-2. doi: 10.1097/00004770-200103000-00010.
Alkaline phosphatase (ALP) seems to be important in the formation of mineralized tissues. High levels of ALP have been demonstrated in dental pulp cells. In the present study ALP activity was analyzed in normal healthy human dental pulps, in reversible pulpitis, and in irreversible pulpitis. Enzymatic ALP control values for the normal healthy pulps were 110.96+/-20.93. In the reversible pulpitis specimens the ALP activity increased almost eight times to 853.6+/-148.27. In the irreversible pulpitis specimens the values decreased sharply to 137.15+/-21.28 and were roughly equivalent to those seen in normal healthy pulps. The differences between the groups (control vs. reversible pulpitis and reversible pulpitis vs. irreversible pulpitis) were statistically significant. These results could point to a role of ALP in the initial pulp response after injury.
碱性磷酸酶（ALP）似乎在矿化组织的形成中起重要作用。牙髓细胞中已证实存在高水平的ALP。在本研究中，对正常健康人牙髓、可逆性牙髓炎和不可逆性牙髓炎中的ALP活性进行了分析。正常健康牙髓的酶促ALP对照值为110.96±20.93。在可逆性牙髓炎标本中，ALP活性几乎增加了八倍，达到853.6±148.27。在不可逆性牙髓炎标本中，该值急剧下降至137.15±21.28，大致与正常健康牙髓中的值相当。各组之间（对照组与可逆性牙髓炎组以及可逆性牙髓炎组与不可逆性牙髓炎组）的差异具有统计学意义。这些结果可能表明ALP在损伤后牙髓的初始反应中起作用。
