Reynolds C F, Kupfer D J, Christiansen C L, Auchenbach R C, Brenner R P, Sewitch D E, Taska L S, Coble P A
J Nerv Ment Dis. 1984 Jan;172(1):41-4. doi: 10.1097/00005053-198401000-00009.
Multiple Sleep Latency Test (MSLT) findings in a case of Kleine-Levin syndrome are reported for the first time. MSLT data indicate sleepiness as severe as in narcolepsy or obstructive sleep apnea and the occurrence of four sleep onset rapid eye movement (REM) periods, with a greater REM propensity at 2:00 p.m. and 4:00 p.m. than at 10:00 a.m. and 12:00 noon. The replication of such findings might suggest that Kleine-Levin syndrome could be considered a form of periodic REM sleep disinhibition. Therefore, the traditional hypothesis of diencephalic dysfunction may require modification to include the role of more caudal brain stem structures specifically activated during REM sleep.
首次报告了一例克莱恩-莱文综合征患者的多次睡眠潜伏期试验（MSLT）结果。MSLT数据表明，其嗜睡程度与发作性睡病或阻塞性睡眠呼吸暂停一样严重，且出现了四个睡眠起始快速眼动（REM）期，下午2点和4点的REM倾向比上午10点和中午12点时更强。这些结果的重现可能表明，克莱恩-莱文综合征可被视为一种周期性REM睡眠抑制障碍的形式。因此，关于间脑功能障碍的传统假说可能需要修正，以纳入在REM睡眠期间被特异性激活的更靠尾端的脑干结构的作用。
