Piecuch J F, Fedorka N J
J Oral Maxillofac Surg. 1983 Dec;41(12):801-6. doi: 10.1016/s0278-2391(83)80047-0.
Sixteen replamineform hydroxyapatite implants were inserted subperiosteally on the residual ridge in five dogs, and various soft-tissue procedures were performed at intervals of one, two, three, and 27 months after implantation. Three implants served as controls. Twelve of the 13 surgical sites healed normally, including four of the five vestibuloplasties and all eight exposure sites. All 16 implants were still in place and firmly attached to the alveolar bone at the time of sacrifice. A normal stratified squamous epithelium was formed in all specimens in which complete healing occurred. No evidence of an inflammatory reaction was found in response to the soft-tissue surgery in the specimens that healed. The favorable results of this study form the basis for proposed human clinical trials to evaluate the response of the implant and the overlying soft tissues to a dental prosthesis.
在五只狗的残余牙槽嵴上骨膜下植入了16颗再塑形羟基磷灰石种植体，并在植入后1个月、2个月、3个月和27个月时分别进行了不同的软组织手术。3颗种植体作为对照。13个手术部位中有12个正常愈合，包括5个前庭成形术中的4个以及所有8个暴露部位。在处死动物时，所有16颗种植体仍在位并牢固地附着于牙槽骨。在所有完全愈合的标本中均形成了正常的复层鳞状上皮。在愈合的标本中，未发现对软组织手术有炎症反应的迹象。本研究的良好结果为拟进行的人体临床试验奠定了基础，以评估种植体及覆盖的软组织对牙修复体的反应。
