Krell R D
Eur J Pharmacol. 1978 May 15;49(2):151-5. doi: 10.1016/0014-2999(78)90071-7.
The response of isolated canine bronchial smooth muscle to several agonists was investigated. Carbachol, serotonin, histamine and acetylcholine, in that order of potency, elicited a concentration-related contraction of bronchial smooth muscle. The maximal contractions produced by histamine and serotonin were somewhat less than those obtained with carbachol. Prostaglandin F2alpha and bradykinin failed to cause contraction. Bronchial smooth muscle strips in which a tone was induced with submaximal concentrations of carbachol underwent a concentration-related relaxation when exposed to prostaglandin E2,(+/-)-isoprenaline and (--)-norepinephrine, in that order of potency. Bradykinin, in three of four experiments, failed to relax the tissue.
研究了离体犬支气管平滑肌对几种激动剂的反应。卡巴胆碱、5-羟色胺、组胺和乙酰胆碱，按效力顺序依次引起支气管平滑肌浓度相关的收缩。组胺和5-羟色胺产生的最大收缩略小于卡巴胆碱引起的最大收缩。前列腺素F2α和缓激肽未能引起收缩。用亚最大浓度的卡巴胆碱诱导产生张力的支气管平滑肌条，当暴露于前列腺素E2、（±）-异丙肾上腺素和（-）-去甲肾上腺素时，按效力顺序依次经历浓度相关的舒张。在四个实验中的三个实验中，缓激肽未能使组织舒张。
