Sampson S R, Weiss-Rotem C
Br J Pharmacol. 1982 Feb;75(2):287-91. doi: 10.1111/j.1476-5381.1982.tb08784.x.
The effect of lithium was studied on resting tension of guinea-pig spiral tracheal strips and their responses to carbachol and histamine in vitro. Lithium reversibly relaxed tracheal smooth muscle in a dose-dependent manner. In addition, lithium increased the ED50 for carbachol 10 fold and that for histamine by over 100 fold; maximum responses for each agonist were also reduced. Lithium-induced relaxation of tracheal smooth muscle was unaffected by changes in extracellular calcium concentration over the range 0-11 mM, verapamil, ouabain, procaine, propranolol or reduction in extracellular sodium concentration. The ability of lithium to reduce carbachol- and histamine-induced contraction of tracheal smooth muscle was also not altered by propranolol, procaine, ouabain, verapamil or lowered extracellular sodium. We conclude that lithium acts directly on tracheal smooth muscle to relax it by an as yet unknown mechanism. This may or may not be related to the ability of this agent to alter agonist-induced contraction of tracheal smooth muscle.
研究了锂对豚鼠螺旋形气管条静息张力及其在体外对卡巴胆碱和组胺反应的影响。锂以剂量依赖性方式可逆地舒张气管平滑肌。此外，锂使卡巴胆碱的半数有效剂量（ED50）增加了10倍，使组胺的ED50增加了100倍以上；每种激动剂的最大反应也降低了。在0至11 mM的细胞外钙浓度范围内，锂诱导的气管平滑肌舒张不受维拉帕米、哇巴因、普鲁卡因、普萘洛尔或细胞外钠浓度降低的影响。普萘洛尔、普鲁卡因、哇巴因、维拉帕米或降低的细胞外钠也不会改变锂降低卡巴胆碱和组胺诱导的气管平滑肌收缩的能力。我们得出结论，锂通过一种尚不清楚的机制直接作用于气管平滑肌使其舒张。这可能与也可能不与该药物改变激动剂诱导的气管平滑肌收缩的能力有关。
