Fujimaki Y, Kawamura S, Sugita R
Jpn J Antibiot. 1983 Jun;36(6):1317-24.
The tissue specimens were taken to evaluate the efficacy of cefotetan (CTT), a new cephamycin antibiotic, for otorhinolaryngological infectious diseases. The concentrations of CTT in palatine tonsils, maxillary sinus mucosa, wall of maxillary sinus cysts, discharge from otitis media and saliva were studied. The serum level determined at 3 hours following intravenous injection of 1 g of the drug was 49.2 micrograms/ml (n = 4). The serum level at 12 hours following intravenous injection of 2 g of the drug was 14.4 micrograms/ml (n = 4). 15-25% of the serum levels of CTT were demonstrated in palatine tonsils, 20.7-35.7% in maxillary sinus mucosa. We detected high levels of CTT in the effusion of acute maxillary sinusitis, 24.0 micrograms/ml (2 g, i.v., 90 min.), 26.3 micrograms/ml (1 g, i.v., 120 min.). On the other hand, we detected only a few per cent of the serum level of CTT in the effusion of chronic maxillary sinusitis.
采集组织样本以评估新型头孢霉素类抗生素头孢替坦（CTT）治疗耳鼻咽喉科感染性疾病的疗效。研究了CTT在腭扁桃体、上颌窦黏膜、上颌窦囊肿壁、中耳炎分泌物及唾液中的浓度。静脉注射1 g该药后3小时测得的血清浓度为49.2微克/毫升（n = 4）。静脉注射2 g该药后12小时的血清浓度为14.4微克/毫升（n = 4）。腭扁桃体中CTT的血清浓度为15 - 25%，上颌窦黏膜中为20.7 - 35.7%。在急性上颌窦炎的渗出物中检测到高水平的CTT，分别为24.0微克/毫升（静脉注射2 g，90分钟）、26.3微克/毫升（静脉注射1 g，120分钟）。另一方面，在慢性上颌窦炎的渗出物中仅检测到血清浓度百分之几的CTT。
