Yanagisawa T, Satoh K, Taira N
Eur J Pharmacol. 1978 May 15;49(2):189-92. doi: 10.1016/0014-2999(78)90077-8.
4-Aminopyridine injected into the sinus node artery produced a long-lasting decrease in sinus rate preceded by a transient increase. With a large dose, a long-lasting increase in sinus rate was superimposed on the long-lasting decrease phase. The long-lasting decrease and increase in sinus rate were abolished by 1-hyoscyamine and propranolol respectively, and both were reduced by tetrodotoxin. These results can be interpreted as being due to excitation of autonomic nerves by 4-aminopyridine.
将4-氨基吡啶注入窦房结动脉会使窦性心率出现先短暂升高随后持久降低的情况。大剂量时，在持久降低阶段会叠加窦性心率的持久升高。窦性心率的持久降低和升高分别被东莨菪碱和普萘洛尔消除，且两者都被河豚毒素减弱。这些结果可解释为是由于4-氨基吡啶对自主神经的兴奋作用所致。
