Russell G I, Bing R F, Taverner D, Swales J D, Thurston H
Proc Eur Dial Transplant Assoc. 1983;20:546-50.
The possible vasodepressor role of the renal medulla was studied by chemical medullectomy (i.v. bromoethylamine hydrobromide) in rats. A significant increase in blood pressure (BP) was observed 10 weeks after injection which related to the increase in urinary volume and decrease in urinary prostaglandin E2 (PGE2) in medullectomised rats, but not to plasma renin concentration (PRC). Creatinine clearance was unchanged. The differences between control and medullary damaged rats were maintained over a wide range of sodium intakes although the patterns of response were similar in the two groups. The increase in BP observed following renal medullectomy is likely to be secondary to a reduction in interstitial cell function.
通过对大鼠进行化学性肾髓质切除（静脉注射氢溴酸溴乙胺），研究了肾髓质可能的血管减压作用。注射后10周观察到血压显著升高，这与去肾髓质大鼠尿量增加和尿前列腺素E2（PGE2）减少有关，但与血浆肾素浓度（PRC）无关。肌酐清除率未改变。尽管两组的反应模式相似，但在广泛的钠摄入量范围内，对照组和肾髓质损伤大鼠之间的差异仍然存在。肾髓质切除后观察到的血压升高可能继发于间质细胞功能的降低。
