Oxenkrug G F, Pomara N, McIntyre I M, Branconnier R J, Stanley M, Gershon S
Psychiatry Res. 1983 Oct;10(2):125-30. doi: 10.1016/0165-1781(83)90111-7.
Cortisol resistance to suppression by 0.5 mg of dexamethasone given at 11 p.m. was studied in 30 normal subjects, 17 to 78 years of age. Serum cortisol concentrations were determined by radioimmunoassay. A strong positive correlation was found between age and cortisol concentrations 9 hours after dexamethasone administration. The data suggest that aging, per se, might contribute to the increased cortisol resistance to suppression by dexamethasone reported in depression and dementia.
对30名年龄在17至78岁的正常受试者进行了研究，观察晚上11点给予0.5毫克地塞米松后皮质醇的抑制抵抗情况。采用放射免疫分析法测定血清皮质醇浓度。发现年龄与地塞米松给药后9小时的皮质醇浓度之间存在强正相关。数据表明，衰老本身可能导致抑郁症和痴呆症中报道的皮质醇对地塞米松抑制的抵抗增加。
