Hankin F M, Louis D S
J Pediatr Orthop. 1984 Jan;4(1):96-9. doi: 10.1097/01241398-198401000-00018.
The advent of potent chemotherapeutic agents has been helpful in the medical management of a variety of malignancies. Unfortunately, the side effects and complications have been significant. Our recent experience with a patient who had the avoidable complication of extravasation with doxorubicin (Adriamycin) into the upper extremity is described. Frequently, the medical management of this problem has been observation alone followed by late surgical referral. This tissue fixation of the chemotherapeutic agent is such that it stays bound locally and causes an ever enlarging ulceration of tissue. This slough can occur not only in a circumferential fashion, but also in the superficial to deep manner, resulting in full-thickness lesions. Early surgical intervention is important to shorten the morbidity and to return the patients to their home environment.
强效化疗药物的出现有助于多种恶性肿瘤的医学治疗。不幸的是，其副作用和并发症也很严重。本文描述了我们最近遇到的一位患者，该患者出现了阿霉素（ Adriamycin）渗漏至上肢这一可避免的并发症。通常，对于这个问题的医学处理方式仅是观察，随后再进行晚期手术转诊。化疗药物在组织中的固定情况是，它会局部黏附并导致组织溃疡不断扩大。这种组织脱落不仅可能呈环形发生，还可能从浅表到深部发展，导致全层病变。早期手术干预对于缩短发病时间并使患者恢复正常生活环境很重要。
